解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::C-reactive protein (CRP) has been demonstrated to induce blood-brain barrier disruption (BBB) involving NAD(P)H-oxidase dependent oxidative stress. It is unclear why CRP affects the BBB and not other vascular beds following stroke. Therefore we examined CRP receptor and NAD(P)H-oxidase expression levels in bovine brai...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.011
更新日期:2010-05-01 00:00:00
abstract::The objective of this study was to investigate the effects of the cytokines IFN-alpha, IL-6 and IL-10 present in the serum of systemic lupus erythematosus (SLE) patients on the differentiation and maturation of DCs derived from CD34(+) hematopoietic precursor cells (HPCs). CD34(+) HPCs cultured in SLE serum containing...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.017
更新日期:2010-05-01 00:00:00
abstract::Human milk is a complex biological fluid. It contains many nutrients, anti-infectious and biologically active substance. Human milk also contains many angiogenic polypeptides. We have determined four of these: Vascular endothelial growth factor (VEGF), basic fibroblast growth factor (b-FGF), insulin-like growth factor...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2010.02.008
更新日期:2010-05-01 00:00:00
abstract::The interleukin (IL)-7 receptor (IL-7R) is expressed on human pre-B but not mature B-cells. We hypothesised that aberrant expression of IL-7R contributes to B-cell oncogenesis. Surface expression of IL-7R components CD127 and CD132, and intracellular Ki-67 and Bcl-2 were examined by flow cytometry on peripheral blood ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.12.001
更新日期:2010-04-01 00:00:00
abstract::Tumor necrosis factor-alpha (TNF) is expressed on the cell surface as a transmembrane form (tmTNF), that can be released as a soluble form (solTNF) via proteolytic cleavage. These two types of TNF exert their biological functions by binding to one of two TNF receptors, TNFR1 or TNFR2. However, the biological function ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.11.022
更新日期:2010-04-01 00:00:00
abstract::Treatment of non-small cell lung carcinoma (NSCLC) remains at a disappointingly low success rate. Not only is metastatic spread common in NSCLC, but therapeutic success decreases dramatically once metastases are present. Understanding factors which contribute to poor prognosis in NSCLC is critical for development of m...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.11.015
更新日期:2010-03-01 00:00:00
abstract:OBJECTIVE:Atherosclerosis is a chronic inflammatory disease regulated by T lymphocyte subsets. Recently, CD4(+) CD25(+) Foxp3(+) regulatory T (Treg) cells and Th17 cells have been described as two distinct subsets and have the opposite effects on autoimmunity. Clinical observation has revealed that the Th17/Treg imbala...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.09.007
更新日期:2010-02-01 00:00:00
abstract::The pathogenesis of rheumatoid arthritis (RA) and psoriatic arthritis (PsA) involves an abnormal chemokine regulation. The chemokine receptor CCR4 is necessary for T cell migration to the skin. We, therefore, studied if CCR4 and its ligand macrophage-derived chemokine (MDC/CCL22) could participate in spreading the dis...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.10.005
更新日期:2010-01-01 00:00:00
abstract::The pathogenesis of sickle cell disease (HbSS), which has numerous complications including stroke, involves inflammation resulting in alteration of plasma inflammatory protein concentration. We investigated HbSS children with abnormal cerebral blood flow detected by trans-cranial Doppler ultrasound (TCD) who participa...
journal_title:Cytokine
pub_type: 杂志文章,随机对照试验
doi:10.1016/j.cyto.2009.10.002
更新日期:2010-01-01 00:00:00
abstract::The gene polymorphisms interferon-gamma (IFN-gamma) +874 T/A and interleukin (IL)-4 -590 C/T have been associated with the altered production of cytokines. Therefore, they might be indicative of the occurrence of Paracoccidioidomycosis (PCM) caused by Paracoccidioides brasiliensis. The analysis of single nucleotide po...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.07.011
更新日期:2009-12-01 00:00:00
abstract::The aim of this study was to characterize the association between adipocyte enlargement and circulating levels of serum amyloid A (SAA). Furthermore, we wanted to search for possible associations with measures of glycemic control and levels of circulating adipokines and/or inflammatory markers in men and women with a ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.08.005
更新日期:2009-12-01 00:00:00
abstract::Inflammatory bowel disease is a disease that reflects a disequilibrium in host-commensal homeostasis. T-bet-/-xRAG2-/- deficient mice develop a spontaneous juvenile ulcerative colitis resulting from a pro-inflammatory response to the commensal microbiota that is dendritic cell and TNF-alpha driven [schematized in Fig....
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2009.07.007
更新日期:2009-10-01 00:00:00
abstract::Tumor necrosis factor (TNF) and the members of the interferon (IFN) family are major inducible cytokines that function to counteract viral infections or cellular transformation. Recently, our lab has characterized a novel antiviral state which is induced in primary human fibroblasts by co-treatment with TNF plus IFNbe...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.06.006
更新日期:2009-09-01 00:00:00
abstract::The objectives were to determine if blood IL-10 levels rise during the early stages of acute (wasting) pre-pubescent malnutrition in metabolically distinct murine models known to depress inflammatory immune competence and whether systemic IL-10 production is affected in these pathologies. Weanling C57BL/6J mice were a...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.05.015
更新日期:2009-08-01 00:00:00
abstract:BACKGROUND:Although transforming growth factor-beta (TGF-beta), a growth regulator of hepatocytes, induces cell death under pathological conditions, responsiveness of hepatocytes to hypoxic stimulus has not been fully defined. This study aimed at investigating the role of TGF-beta1 in hypoxia-induced hepatotoxicity usi...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.004
更新日期:2009-07-01 00:00:00
abstract::To clarify the interactions between dendritic cells (DCs) and Th1 and Th17 T cell subsets and the mode of action of IVIG in inflammatory myopathies, Expression of CD4(+) and CD8(+) T cells, immature (CD1a) and mature (DC-LAMP) DCs, interleukin-17 (IL-17) and interferon-gamma (IFN-gamma), was quantified by immunohistoc...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.02.013
更新日期:2009-06-01 00:00:00
abstract::Estrogens have been associated with risk for epithelial ovarian cancer (OVCA). Both IL-6 and IL-8 are also likely involved in the progression of OVCA. In order to discover the underline molecular mechanism, we investigated the modulation of estrogen and two cytokines in the growth and progression of epithelial OVCA. I...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.013
更新日期:2009-06-01 00:00:00
abstract:BACKGROUND:HIV-1 and HIV-2 are two related viruses with distinct clinical outcomes, where HIV-1 is more pathogenic and transmissible than HIV-2. The pathogenesis of both infections is influenced by the dysregulation and deterioration of the adaptive immune system. However, their effects on the responsiveness of innate ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.03.003
更新日期:2009-06-01 00:00:00
abstract::This moleculo-epidemiological and immunological study through cytokine response assessment was done to know the dynamics of cytokines in the initiation, persistence and association to physiological changes of a particular pathogen in water buffaloes. This is important to understand the magnitude and behavior of diseas...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.02.006
更新日期:2009-05-01 00:00:00
abstract::This study was aimed to assess whether ex vivo treatment with granulocyte-colony stimulating factor (G-CSF) modifies biological properties of bone marrow stromal cells (BMSC) and enhances functional recovery by BMSC transplantation into infarct brain. Immunohistochemistry was conducted to characterize the cultured BMS...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2009.02.008
更新日期:2009-05-01 00:00:00
abstract::Interleukin-8 (IL-8/CXCL8) is widely expressed in fetal tissues although inflammatory changes are not seen. Circulating IL-8 is comprised of an endothelial-derived [ala-IL-8](77) isoform and another, more potent [ser-IL-8](72) secreted by most other cells; [ala-IL-8](77) can be converted into [ser-IL-8](72) by proteol...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.12.022
更新日期:2009-04-01 00:00:00
abstract:INTRODUCTION:Adipocytokines represent a molecular link between metabolic factors and vascular function. The purpose of our study was to investigate the relationship between adiponectin, leptin and renal function parameters in patients with glomerular filtration rate (GFR) above 90 ml/min/m(2) and type 2 diabetes. MATE...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1016/j.cyto.2009.01.001
更新日期:2009-04-01 00:00:00
abstract::Farnesol, a quorum-sensing molecule, regulates virulence and morphogenesis in Candida albicans and is involved in various human pathologies including oral candidiasis. Oral epithelial cells are involved in innate immunity against Candida infections via Toll-like receptors (TLRs) and inflammatory mediators. We investig...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.11.011
更新日期:2009-02-01 00:00:00
abstract::We recently reported an association between interleukin-6 (IL6) polymorphisms (SNPs) and haplotypes and aggressive periodontitis (AgP). The aim of this study was to investigate this association in a larger cohort of subjects, affected by either aggressive or chronic periodontitis. Five IL6 SNPs were analyzed in 765 su...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.016
更新日期:2009-01-01 00:00:00
abstract:OBJECTIVES:The fact that ovarian cancer remains confined to the peritoneal cavity even in advanced stages has allowed us to surmise that local immunosuppressive factors could be involved in the tumor biology of ovarian cancer. In this context, IL-10 can be one of the key factors. By studying the kinetics of IL-10 conce...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.019
更新日期:2009-01-01 00:00:00
abstract::Increased cerebrospinal fluid (CSF) IL-6 has been reported in patients with Behçet's disease (BD) and neurological involvement. To elucidate the value of IL-6 as a marker of disease activity, serum and CSF IL-6 levels of 68 BD patients with acute (26) or chronic progressive (14) parenchymal involvement (pNB), dural si...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.007
更新日期:2008-12-01 00:00:00
abstract::Cartilage-specific extracellular matrix synthesis is the prerequisite for chondrocyte survival and cartilage function, but is affected by the pro-inflammatory cytokine TNF-alpha in arthritis. The aim of the present study was to characterize whether the immunoregulatory cytokine IL-10 might modulate cartilage matrix an...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.10.012
更新日期:2008-12-01 00:00:00
abstract::Burn injury is associated with profound inflammation and activation of the innate immune system involving gammadelta T-cells. Similarly, Toll-like receptors (TLR) are associated with activation of the innate immune response; however, it is unclear whether TLR expression is altered in gammadelta T-cells after major bur...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.09.001
更新日期:2008-12-01 00:00:00
abstract::Helminths and their products have a profound immunomodulatory effect upon the inductive and effector phases of inflammatory responses, including allergy. We have demonstrated that PAS-1, a protein isolated from Ascaris suum worms, has an inhibitory effect on lung allergic inflammation due to its ability to down-regula...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.09.005
更新日期:2008-12-01 00:00:00
abstract::Over the last several years, there has been increasing interest in the role of proteins of the TIM (T cell immunoglobulin and mucin domain) family in regulating immune responses. Despite what the name suggests, proteins of this family function in a much more widespread manner than just on T cells, as we will discuss i...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2008.06.013
更新日期:2008-10-01 00:00:00
abstract::Interleukin-4 (IL-4) is a pleiotropic cytokine with broad spectrum of biological effects on target cells. This study deals with the mammalian expression of canine IL-4 (cIL-4) in canine articular chondrocytes (CAC) and its ability to down-regulate pro-inflammatory cytokines, enzyme mediators and their catabolites. We ...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.07.470
更新日期:2008-10-01 00:00:00
abstract::We evaluated the spontaneous IL17, IFNgamma and IL10 production by peripheral blood mononuclear cells from patients affected by clinically isolated syndromes (CIS) suggestive of multiple sclerosis (MS) both in acute phase and in remission, relapsing remitting MS (RRMS) both in relapse and in remission, not-relapsing s...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.08.007
更新日期:2008-10-01 00:00:00
abstract::MicroRNAs (miRs) were only discovered little more than a decade ago, yet it has become rapidly clear that they are crucial posttranscriptional regulators of gene expression by decreasing the abundance or translational efficiency of mRNAs [Maroney PA, Yu Y, Nilsen TW. MicroRNAs, mRNAs, and translation. Cold Spring Harb...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2008.07.016
更新日期:2008-09-01 00:00:00
abstract::Cell death and innate immunity are ancient evolutionary conserved processes that utilize a dazzling number of related molecular effectors and parallel signal transduction mechanisms. The investigation of the molecular mechanisms linking the sensing of a danger signal (pathogens or tissue damage) to the induction of an...
journal_title:Cytokine
pub_type: 杂志文章,评审
doi:10.1016/j.cyto.2008.07.015
更新日期:2008-09-01 00:00:00
abstract::The proper balance between IL-12p40-related cytokines controls the appearance of normal and pathological Th1 immune responses. In this study, we examined the inducible IL-12p40, IL-12p35 and IL-23p19 mRNA expression and protein production in human peripheral blood mononuclear cells (PBMC) and purified monocytes, isola...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.04.003
更新日期:2008-07-01 00:00:00
abstract::The aims of this study were to examine associations between two SNPs in the human IL-15 gene and three SNPs in the IL-15Ralpha gene with predictors of metabolic syndrome and phenotypes in muscle, strength, and bone at baseline and in response to resistance training (RT). Subjects were Caucasians who had not performed ...
journal_title:Cytokine
pub_type: 杂志文章,多中心研究
doi:10.1016/j.cyto.2008.04.008
更新日期:2008-07-01 00:00:00
abstract::T cells and T cell derived cytokines are involved in the complex pathogenesis of asthma. The role of the cytokine IL-18 however, is not clearly defined so far. On the one hand side IL-18 induces Th1-type cytokines and thereby might counter-regulate Th2-mediated allergic asthma. On the other hand IL-18 also bears pro-i...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.02.012
更新日期:2008-06-01 00:00:00
abstract::Interleukin (IL)-33 (or IL-1F11) was recently identified as a ligand for the orphan IL-1 receptor family member T1/ST2 (ST2). IL-33 belongs to the IL-1 cytokine family and, upon binding to ST2, induces intracellular signals similar to those utilized by IL-1. The effects of other IL-1 family cytokines are mediated by t...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2008.03.008
更新日期:2008-06-01 00:00:00
abstract::We analyzed the gut immune stimulation induced by Gram-positive bacteria: non probiotic Lactobacillus acidophilus CRL 1462 and Lactobacillus acidophilus A9; two potentially probiotic strains: L. acidophilus CRL 924 and Lactobacillusdelbrueckii subsp. bulgaricus CRL 423; comparatively with a probiotic strain: Lactobaci...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.11.014
更新日期:2008-03-01 00:00:00
abstract::Interferon (IFN)-alpha and -beta are important antiviral mediators. IFN-alpha is widely used for the treatment of chronic hepatitis B. In our previous studies, a subtype of woodchuck IFN-alpha (wIFN-alpha) was characterized and has been shown to be active in suppressing the replication of woodchuck hepatitis virus (WH...
journal_title:Cytokine
pub_type: 杂志文章
doi:10.1016/j.cyto.2007.11.002
更新日期:2008-02-01 00:00:00